anhydrase II (CAII)

By Targets:	Carbonic Anhydrase (14) Apoptosis (1) GLUT (1) Isotope-Labeled Compounds (2) Phosphatase (1) Phosphodiesterase (PDE) (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (1) Neurological Disease (4)

Targets Recommended: Photosystem II Carbonic Anhydrase CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0109A

Dorzolamide hydrochloride 3 Publications Verification L671152 hydrochloride; MK507 hydrochloride	Carbonic Anhydrase	Others
Dorzolamide (L671152) hydrochloride is a potent *carbonic anhydrase* II inhibitor, with IC₅₀** values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-151493

CAII-IN-1	Carbonic Anhydrase	Cancer
CAII-IN-1 (compound 3n), a thiosemicarbazide derivative, is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 10.3 µM for bovine CA-II. CAII-IN-1 can be used in research of carbonic anhydrase related biological disorders .

HY-151494

CAII-IN-2	Carbonic Anhydrase	Cancer
CAII-IN-2 (compound 3g), a thiosemicarbazide derivative, is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 12.1 µM for bovine CA-II. CAII-IN-2 can be used in research of carbonic anhydrase related biological disorders .

HY-151495

CAII-IN-3

Carbonic Anhydrase Cancer

CAII-IN-3 (compound 3h), a thiosemicarbazones derivatives, is a potent carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 13.4 µM .

CAII-IN-3	Carbonic Anhydrase	Cancer
CAII-IN-3 (compound 3h), a thiosemicarbazones derivatives, is a potent carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 13.4 µM .

HY-B0109

Dorzolamide L671152; MK507	Carbonic Anhydrase	Cancer
Dorzolamide (L671152) is a potent *carbonic anhydrase* II inhibitor, with IC₅₀** values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-157139

ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase Phosphatase	Inflammation/Immunology
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual *carbonic anhydrase* (CA) and alkaline phosphatase (ALP)** inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .

HY-B0588A

Brinzolamide hydrochloride AL-4862 hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide (AL-4862) hydrochloride is a selective *carbonic anhydrase* II inhibitor with an IC₅₀** value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-B0588

Brinzolamide 3 Publications Verification AL-4862	Carbonic Anhydrase	Others Neurological Disease
Brinzolamide (AL-4862) is a selective *carbonic anhydrase* II** inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

HY-B0109S

Dorzolamide-d5	Isotope-Labeled Compounds Carbonic Anhydrase	Cancer
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].

HY-B0109AR

Dorzolamide hydrochloride (Standard) L671152 hydrochloride(Standard); MK507 hydrochloride (Standard)	Carbonic Anhydrase	Others
Dorzolamide (hydrochloride) (Standard) is the analytical standard of Dorzolamide (hydrochloride). This product is intended for research and analytical applications. Dorzolamide (L671152) hydrochloride is a potent *carbonic anhydrase* II inhibitor, with IC₅₀** values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0109AS

Dorzolamide-d3 hydrochloride L671152-d₃ hydrochloride; MK507-d₃ hydrochloride	Carbonic Anhydrase Isotope-Labeled Compounds	Others
Dorzolamide-d₃ hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent *carbonic anhydrase* II inhibitor, with IC₅₀** values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-151916

Enpp/Carbonic anhydrase-IN-1	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC₅₀s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .

HY-B0588AS

Brinzolamide-d5 hydrochloride AL-4862-d₅ hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride[1]. Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[2][3].

HY-B0588R

Brinzolamide (Standard) AL-4862 (Standard)	Carbonic Anhydrase	Others Neurological Disease
Brinzolamide (Standard) is the analytical standard of Brinzolamide. This product is intended for research and analytical applications. Brinzolamide (AL-4862) is a selective *carbonic anhydrase* II** inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

HY-151486

GLUT1-IN-1	GLUT	Cancer
GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC₅₀ values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer .

Species:	Human (3) Mouse (1)
Tag:	His (4)
Source:	HEK293 (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P78746

	Carbonic Anhydrase 2 Protein, Human (HEK293, His) CA2; CA-II; CAII; Car2	Human	HEK293
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Human (HEK293, His) is 260 a.a., with molecular weight of approximately 31.72 kDa.

HY-P72861

	Carbonic Anhydrase 2 Protein, Mouse (His) Carbonic anhydrase 2; Carbonic anhydrase C; CAC; CA-II; CA2	Mouse	HEK293
	Carbonic Anhydrase 2 Protein is a member of the carbonic anhydrase isozyme family, responsible for catalyzing the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. CA2 plays vital role in the regulation of ion transport and pH balance and is involved in many biological processes. Carbonic Anhydrase 2 Protein, Mouse (His) is the recombinant mouse-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Mouse (His) is 259 a.a., with molecular weight of 30-35 kDa.

HY-P72860A

	Carbonic Anhydrase 2 Protein, Human (C-His) Carbonic anhydrase 2; Carbonic anhydrase C; CAC; CA-II; CA2	Human	E. coli
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (C-His) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Human (C-His) is 259 a.a., with molecular weight of ~33.05 kDa.

HY-P72860

	Carbonic Anhydrase 2 Protein, Human (C-His, Solution) Carbonic anhydrase 2; Carbonic anhydrase C; CAC; CA-II; CA2	Human	E. coli
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is 259 a.a., with molecular weight of ~30 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-B0109S

Dorzolamide-d5
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].

HY-B0109AS

Dorzolamide-d3 hydrochloride
Dorzolamide-d₃ hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent *carbonic anhydrase* II inhibitor, with IC₅₀** values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0588AS

Brinzolamide-d5 hydrochloride
Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride[1]. Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[2][3].

Brinzolamide-d5 hydrochloride

Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride[1]. Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P83617

Carbonic Anhydrase 2 Antibody (YA3362)

CA2; Carbonic anhydrase 2; Carbonate dehydratase II; Carbonic anhydrase C; CAC; Carbonic anhydrase II; CA-II
WB, IHC-P Human, Mouse, Rat

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